Manipulating the Genome

More groundbreaking publications nominated by our editors

Enjoy free access until October 31st 2018. Open access articles are freely available online on a permanent basis.


A comparison of CRISPR/Cas9 and siRNA-mediated ALDH2 gene silencing in human cell lines


L_springer_mini_logo

A method for the production and expedient screening of CRISPR/Cas9-mediated non-transgenic mutant plants


L_natureresearch_mini_logo

Am I ready for CRISPR? A user's guide to genetic screens


L_natureresearch_mini_logo

BE-PLUS: a new base editing tool with broadened editing window and enhanced fidelity


L_natureresearch_mini_logo

Beyond editing: repurposing CRISPR–Cas9 for precision genome regulation and interrogation


L_natureresearch_mini_logo

Characterization of ent-kaurene synthase and kaurene oxidase involved in gibberellin biosynthesis from Scoparia dulcis


L_springer_mini_logo

CRISPR/Cas9 editing of carotenoid genes in tomato

L_springer_mini_logo

CRISPR/Cas9 genome editing in wheat


L_springer_mini_logo

CRISPR/Cas9-based genetic correction for recessive dystrophic epidemolysis bullosa


L_natureresearch_mini_logo

CRISPR/Cas9-mediated PD-1 disruption enhances anti-tumor efficacy of human chimeric antigen receptor T cells


L_natureresearch_mini_logo

Designing cell function: assembly of synthetic gene circuits for cell biology applications


L_natureresearch_mini_logo

Effects of clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated (Cas) protein 9 system-Based Deletion of miR-451 in Mouse Embryonic Stem Cells on Their Self-Renewal and Hematopoietic Differentiation


L_springer_mini_logo

Engineered integrative and conjugative elements for efficient and inducible DNA transfer to undomesticated bacteria


L_natureresearch_mini_logo

Engineering bacteria for diagnostic and therapeutic applications


L_natureresearch_mini_logo

Generation of genetically-engineered animals using engineered endonucleases


L_springer_mini_logo

Genetic and epigenetic influences on the loss of tolerance in autoimmunity


L_natureresearch_mini_logo

Genetics of CRISPR arrays in Salmonella Typhimurium 14028 associated with foreign DNA decay


L_springer_mini_logo

The Gene Ontology Handbook


L_springer_mini_logo

Global transcription of CRISPR loci in the human oral cavity


L_brandstrip_bmc

Humanized model mice by genome editing and engraftment technologies


L_springer_mini_logo

Increasing Cas9-mediated homology-directed repair efficiency through covalent tethering of DNA repair template


L_natureresearch_mini_logo

Isolation and structure elucidation of lipopeptide antibiotic taromycin B from the activated taromycin biosynthetic gene cluster


L_natureresearch_mini_logo

Marker-free genetic manipulations in yeast using CRISPR/CAS9 system


L_springer_mini_logo

Methylquercetins stimulate melanin biosynthesis in a three-dimensional skin model


L_springer_mini_logo

Nanoparticle delivery of CRISPR into the brain rescues a mouse model of fragile X syndrome from exaggerated repetitive behaviours


L_natureresearch_mini_logo

Natural product derivative Gossypolone inhibits Musashi family of RNA-binding proteins


L_brandstrip_bmc

Potential of metabolic engineering in bacterial nanosilver synthesis


L_springer_mini_logo

Precision genome engineering through adenine base editing in plants


L_natureresearch_mini_logo

Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage


L_natureresearch_mini_logo

Programmable DNA repair with CRISPRa/i enhanced homology-directed repair efficiency with a single Cas9

L_natureresearch_mini_logo

Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage

L_natureresearch_mini_logo

Protein hyperproduction in fungi by design

L_springer_mini_logo

Recent challenges and advances in genetically-engineered cell therapy

L_springer_mini_logo

Shared genetic etiology of hypertension and stroke: evidence from bioinformatics analysis of genome-wide association studies

L_natureresearch_mini_logo

Stem cells and genome editing: approaches to tissue regeneration and regenerative medicine

L_natureresearch_mini_logo

Study of the link between dopamine transporter gene polymorphisms and response to paroxetin and escitalopram in patients with lifelong premature ejaculation

L_natureresearch_mini_logo

Synthetic biology advances and applications in the biotechnology industry: a perspective

L_springer_mini_logo​​​​​​​

Synthetic hydrogels for human intestinal organoid generation and colonic wound repair.

L_natureresearch_mini_logo​​​​​​​

Targeting of HER3 with Functional Cooperative miRNAs Enhances Therapeutic Activity in HER2-Overexpressing Breast Cancer Cells

L_brandstrip_bmc​​​​​​​

The best Cas scenario

L_natureresearch_mini_logo​​​​​​​

The impact of genome editing on the introduction of monogenic traits in livestock

L_brandstrip_bmc​​​​​​​

The International Mouse Phenotyping Consortium (IMPC): a functional catalogue of the mammalian genome that informs conservation

L_springer_mini_logo​​​​​​​​​​​​​​

The LspC3–41I restriction-modification system is the major determinant for genetic manipulations of Lysinibacillus sphaericus C3–41


L_brandstrip_bmc

Transformation-associated recombination (TAR) cloning for genomics studies and synthetic biology


L_springer_mini_logo

Use of designed sequences in protein structure recognition


L_brandstrip_bmc