Medicine and Public Health

Browse the following groundbreaking articles nominated by our Editors-in-Chief and read why they believe they could help change the world.

Enjoy free access until the end of July, 2018. Open access articles are freely available online on a permanent basis.

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Genome-Edited T Cell Therapies

Current Stem Cell Reports

Offers alternative approaches to conventional drug-based cancer treatments that will change the way we treat cancer.

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2016 European Guidelines on cardiovascular disease prevention in clinical practice

International Journal of Behavioral Medicine

This article provides comprehensive, empirically based advice to help health professionals prevent cardiovascular disease and thus keep people in good health and out of the healthcare system.

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A clinician's guide to microbiome analysis

Nature Reviews Gastroenterology & Hepatology

Must-read advice for clinicians on the rapidly evolving challenges and opportunities for using microbiome analysis to gain insights into patient health.

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Advancing gender equality through the Athena SWAN Charter for Women in Science: an exploratory study of women’s and men’s perceptions

Health Research Policy and Systems

Enabling gender equality in health research: the benefits and limitations of ATHENA Swan.

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Amblyopia treatment of adults with dichoptic training using the virtual reality oculus rift head mounted display: preliminary results

BMC Ophthalmology

This preliminary study shows the potential value of dichoptic training based on a virtual reality head-mounted display in the treatment of adult anisometropic amblyopia.

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An Eight State Study on the Relationships Among Domestic Violence Shelter Services and Residents’ Self-Efficacy and Hopefulness

Journal of Family Violence

Shelters are recommended for domestic violence, but do they actually help victims? The largest study of shelters and victims to-date shows that they do.

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An Examination of Care Practices of Pregnant Women Incarcerated in Jail Facilities in the United States

Maternal and Child Health Journal

This paper highlights the lack of adherence to basic maternal health care standards in US jails, which has rapidly emerged as a central aspect of the opioid crisis. Women in jails are vulnerable, and neglecting their health could have lifelong health consequences.

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An FDA perspective on the assessment of proposed biosimilar therapeutic proteins in rheumatology

Nature Reviews Rheumatology

Insights into the FDA’s roadmap for developing and approving biosimilars, so as to increase patients’ access to important treatments.

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An intravaginal ring that releases three antiviral agents and a contraceptive blocks SHIV-RT infection, reduces HSV-2 shedding, and suppresses hormonal cycling in rhesus macaques

Drug Delivery and Translational Research

This paper describes a safe, acceptable, affordable, and accessible self-initiated multipurpose prevention technology (MPT) that could protect women against the non-curable sexually transmitted infections (STIs) caused by HIV, HSV-2, and HPV, as well as unintended pregnancy and so could significantly improve the health of millions of women globally. 

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Association between initial opioid prescribing prescribing patterns and subsequent long-term use among opiod-naive patients: a statewide retrospective study.

Journal of General Internal Medicine

We are currently witnessing an epidemic of opioid addiction, which is partly fueled by first prescriptions; this highly cited article provides important insights into this problem.

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Automated analysis of free speech predicts psychosis onset in high-risk youths

npj Schizophrenia

People with schizophrenia experience subtle speech problems, even before they first develop psychosis. A computer program that analyzes natural speech could help predict the onset of psychosis in young people at risk.

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Calretinin as a blood-based biomarker for mesothelioma

BMC Cancer

This study was featured in over 50 news outlets. It describes a new blood test that could mean earlier diagnosis for mesothelioma: https://survivingmesothelioma.com/a-new-blood-test-for-mesothelioma/

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Chemical and non-chemical stressors affecting childhood obesity: a systematic scoping review

Journal of Exposure Science and Environmental Epidemiology

A critical review of how the numerous chemical and non-chemical stressors in a child’s environment may combine to affect his or her health.


Development of a recumbent isometric yoga program for patients with severe chronic fatigue syndrome/myalgic encephalomyelitis: A pilot study to assess feasibility and efficacy.

Biopsychosocial Medicine

Yoga for bedridden patients might seem counterintuitive, but this new style of yoga can yield impressive benefits for patients with severe fatigue.

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Efficacy and safety of pertussis vaccination for pregnant women – a systematic review of randomised controlled trials and observational studies

BMC Pregnancy and Childbirth

As pertussis is now a growing threat, vaccination for pregnant women has become more common. This study examines the available evidence on the efficacy and safety of this approach and highlights the need for further research.

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Enhanced Bulbar Function in Amyotrophic Lateral Sclerosis: The Nuedexta Treatment Trial

Neurotherapeutics

In this study, patients with amyotrophic lateral sclerosis (ALS) who received dextromethorphan plus quinidine reported improved speech and swallowing.

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Environmental pollution with antimicrobial agents from bulk drug manufacturing industries in Hyderabad, South India, is associated with dissemination of extended-spectrum beta-lactamase and carbapenemase-producing pathogens

INFECTION

This article highlights the connection between environmental pollution caused by pharmaceutical plants and the spread of multiresistant organisms. It is also a plea for political action in the fight against multiresistance.

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Evidence-Based Social Communication Interventions for Children with Autism Spectrum Disorder

The Indian Journal of Pediatrics

Guidance on interventions for ASD.

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Expert consensus document: Mitochondrial function as a therapeutic target in heart failure

Nature Reviews Cardiology

This Consensus Statement explores mitochondria as a therapeutic target for heart failure, a prevalent condition with a poor prognosis.

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Global aetiology and epidemiology of type 2 diabetes mellitus and its complications

Nature Reviews Endocrinology

In the context of the current epidemic of type 2 diabetes mellitus, this article offers a comprehensive overview of the etiology and epidemiology of the condition and its complications.

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Hand-powered ultralow-cost paper centrifuge

Nature Biomedical Engineering

A 20-cent centrifuge made of paper and string and operated by hand can separate plasma from blood in roughly 90 seconds and be used to effectively diagnose malaria.

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How does the general public view antibiotic use in China? Result from a cross-sectional survey

International Journal of Clinical Pharmacy

This article shows once more the lack of knowledge among the general public regarding antibiotics, which leads to poor antibiotic use, and ultimately to resistance.

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Immunosensors for biomarker detection in autoimmune diseases

Archivum Immunologiae et Therapiae Experimentalis

The authors describe novel biosensors for use in clinical trials regarding autoimmune diseases.

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Impact of weight maintenance and loss on diabetes risk and burden: a population-based study in 33,184 participants

BMC Public Health

A study of over 33,000 people indicates that public health strategies aiming to prevent adult weight gain in the population as a whole have the potential to prevent twice as many cases of type 2 diabetes as strategies that target individuals at high risk of diabetes due to obesity.

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Influence of Pokémon Go on physical activity levels of university players: a cross-sectional study

Int J Health Geographics

Keeping fit by playing a mobile game: the influence of Pokémon Go on the physical activity levels of university athletes.

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Integrating Personalized Technology in Toxicology: Sensors, Smart Glass, and Social Media Applications in Toxicology Research

Journal of Medical Toxicology

This forward-thinking article demonstrates how wearable technology can be used to advance clinical research and improve public health.

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Label-free isolation of prostate circulating tumor cells using Vortex microfluidic technology"

npg | Precision Oncology

A new Vortex Chip isolated 80% of circulating prostate tumor cells, making it a promising new tool in diagnosis and therapeutic decision making for these patients.

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Long non-coding RNA TUG1 promotes cell proliferation and metastasis in human breast cancer

Breast Cancer

This study offers novel insights into the use of long non-coding RNA for detecting and treating breast cancer.

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Long-term survival in patients treated with ruxolitinib for myelofibrosis: COMFORT-I and -II pooled analyses

Journal of Hematology & Oncology

Ruxolitinib is the only approved JAK2 inhibitor for myelofibrosis, thanks to the COMFORT-I and -II studies. Must-read research for all oncologists and hematologist treating patients with myelofibrosis.

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Low-level laser therapy/photobiomodulation in the management of side effects of chemoradiation therapy in head and neck cancer: part 2: proposed applications and treatment protocols.

Journal of Supportive Care in cancer

This paper addresses the use of photobiomodulation with light to decrease the side effects of cancer treatment!

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Maintaining pH-dependent conformational flexibility of M1 is critical for efficient influenza A virus replication

Emerging Microbes & Infections

This article focuses on unraveling the mystery of the flu virus M1 protein to help design better drugs and vaccines to control influenza infections.

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Management of atrial fibrillation in patients taking targeted cancer therapies

Cardio-Oncology

A must-read review for all oncologists and cardiologists treating cancer patients with atrial fibrillation.

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Medication-related osteonecrosis of the jaw: a preliminary retrospective study of 130 patients with multiple myeloma

Maxillofacial Plastic and Reconstructive Surgery

Must-read advice for hematologists and dentists on how to prevent jawbone necrosis in multiple myeloma patients.

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Melanoma: a global perspective

Nature Reviews Cancer

This article emphasizes the importance of studying melanoma in all ethnic groups, not just those of European descent.

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Optimizing patient treatment decisions in an era of rapid technological advances: the case of hepatitis C treatment

Health Care Management Science

By identifying the best choices for providers, the authors have made a tremendous contribution to the treatment of hepatitis C, one of the most debilitating diseases of our time.

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Oral health status in Sichuan Province: findings from the oral health survey of Sichuan, 2015–2016

international journal of oral science

A survey of over 8,000 residents from Sichuan in China found evidence of poor oral health, especially dental caries and periodontal disease.

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Overexpression of lncRNA HOXA11-AS promotes cell epithelial–mesenchymal transition by repressing miR-200b in non-small cell lung cancer

Cancer Cell International

These results demonstrate that lncRNA HOXA11-AS may be a pivotal target for non-small cell lung cancer therapy.

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Painting a new picture of personalised medicine for diabetes

Diabetologia

Precision medicine – the tailoring of healthcare based on an individual’s genetics, lifestyle and environment – represents a new era in diabetes care.

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Particle therapy and nanomedicine: state of art and research perspectives

Cancer Nanotechnology

Summarizes an important direction for the subject.

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Patient-reported outcomes in cancer care — hearing the patient voice at greater volume

Nature Reviews Clinical Oncology

The measurement of patient-reported outcomes can yield more effective care for cancer patients.

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Pregnancy-associated breast cancer: the risky status quo and new concepts of predictive medicine

EPMA Journal

The needs of society at large: highlighting PABC care based on a predictive approach, innovative screening program, targeted prevention, and personalized treatment.

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Publishing in black and white: the relevance of listing of scientific journals.

Rheumatology International

This article conveys a strong message to those who choose scholarly journals as targets for their research and reviews in clinical medicine and rheumatology. Authors should be aware of the best targets and avoid low-quality and potentially unethical sources.

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Quantitative and pathologist-read comparison of the heterogeneity of programmed death-ligand 1 (PD-L1) expression in non-small cell lung cancer

Modern Pathology

Determining which lung cancer patients are likely to respond to PD-1 axis therapies.

Reducing the costs of chronic kidney disease while delivering quality health care: a call to action

Nature Reviews Nephrology

Members of the European Kidney Health Alliance address the economics of CKD, focusing on approaches to prevent CKD and its progression.

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Refining Coats’ disease by ultra-widefield imaging and optical coherence tomography angiography

Graefe's Archive for Clinical and Experimental Ophthalmology

This article offers a unique insight into 20 years of clinical experience and demonstrates the benefits of UWF imaging as a user/patient friendly technique.

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Relationship between sexual position and severity of penile fracture

International Journal of Impotence Research

Though sexuality is a taboo in both the medical community and general populace, sexual health is essential to humanity’s healthy and happy future. 

Sedentary Behavior Research Network (SBRN) – Terminology Consensus Project process and outcome

International Journal of Behavioral Nutrition and Physical Activity

Widely supported, standardized terminology can facilitate future research, interventions, policies, and practices related to sedentary behaviors.

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Severe childhood malnutrition

Nature Reviews Disease Primers

Tackling malnutrition is a major global health priority that is relevant to several of the UN ‘Sustainable Development Goals’ (SDGs) which aim to “end hunger, achieve food security, improve nutrition and promote sustainable agriculture”. This primer explains the consequences of malnutrition in children and outlines key research priorities to tackle this global problem.

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The contraceptive efficacy of intravas injection of Vasalgel™ for adult male rhesus monkeys

Basic and Clinical Andrology

Development of a non-hormonal, long-acting and reversible contraceptive for men could have a significant impact on reducing unintended pregnancies. As such, the use of a nonhuman primate model to evaluate Vasalgel™, a high molecular weight polymer developed as a male contraceptive, represents an important milestone in the development of new male contraceptives.

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The effect of the USPSTF PSA screening recommendation on prostate cancer incidence patterns in the USA

Nature Reviews Urology

An insight into how a change in US policy on screening men for prostate cancer has affected disease patterns.

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Tobacco smoking and multiple sclerosis: a systematic review of systematic and narrative reviews of observational studies

Journal pf Public Health - From Theory to Practise

An important paper relating smoking behavior to multiple sclerosis. Very thoroughly designed from a methodological standpoint, it will be of interest to public health authorities, neurologists and patient self-help groups alike.

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Towards a genomics-informed, real-time, global pathogen surveillance system

Nature Reviews Genetics

This review delineates how genomics can help public health surveillance systems improve the detection of emerging infectious diseases.

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Transcriptionally Active High-Risk Human Papillomavirus is Not a Common Etiologic Agent in the Malignant Transformation of Inverted Schneiderian Papillomas

Head and Neck Pathology 

HPV is not in fact a cause of malignant transformation in sinonasal papilloma.

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Treatment of Depression from a Self-Regulation Perspective: Basic Concepts and Applied Strategies in Self-System Therapy

Cognitive Therapy and Research

Must-read summary by one of today’s most innovative clinical theorists.

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Treatment of infants with Syndromic Robin sequence with modified palatal plates: a minimally invasive treatment option

Head & Face Medicine

This is must-read research for doctors treating upper airway obstructions and feeding problems in children with syndromic Robin sequence. This treatment may help to avoid more invasive interventions in the future.

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U.S. Citizen Children of Undocumented Parents: The Link Between State Immigration Policy and the Health of Latino Children

Journal of Immigrant and Minority Health

Critical information for policymakers and public health professionals on the link between immigration policies and children’s health.

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Update on Fibroid Morcellation

Current Obstetric and Gynecology Reports

Fibroid morcellation is a controversial topic for which the standard of care is rapidly changing.

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Whole-genome sequencing expands diagnostic utility and improves clinical management in paediatric medicine

npj Genomic Medicine

The application of whole genome sequencing has significantly increased our ability to make genetic diagnoses and explain to families why their child is sick. As such, whole genome analysis should become standard procedure at pediatric genetics services.

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Antibiotic treatment for Tuberculosis induces a profound dysbiosis of the microbiome that persists long after therapy is completed

Scientific Reports

Unexpected, long-lasting detrimental effects of standard tuberculosis antibiotic therapy on human gut microbiota and implications for health.

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A New Approach to Deliver Anti-cancer Nanodrugs with Reduced Off-target Toxicities and Improved Efficiency by Temporarily Blunting the Reticuloendothelial System with Intralipid

Scientific Reports

A study that presents practical solutions to drug delivery that translate to real world clinical advances in the treatment of cancer.

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