Genome-wide association studies

Browse key articles nominated by our Editors

A Bioinformatics Approach to the Identification of Variants Associated with Type 1 and Type 2 Diabetes Mellitus that Reside in Functionally Validated miRNAs Binding Sites

from Biochemical Genetics

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A genome-wide association study identifies genomic loci associated with backfat thickness, carcass weight, and body weight in two commercial pig populations

from Journal of Applied Genetics

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A high-quality genome assembly of quinoa provides insights into the molecular basis of salt bladder-based salinity tolerance and the exceptional nutritional value

from Cell Research

 

A large electronic-health-record-based genome-wide study of serum lipids

from Nature Genetics

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A multi-stage genome-wide association study of uterine fibroids in African Americans

from Human Genetics

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A rare missense variant in NR1H4 associates with lower cholesterol levels

from Communications Biology

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Advantages of meta-total RNA sequencing (MeTRS) over shotgun metagenomics and amplicon-based sequencing in the profiling of complex microbial communities

from npj Biofilms and Microbiomes

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An innovative procedure of genome-wide association analysis fits studies on germplasm population and plant breeding

from Theoretical and Applied Genetics

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An integrative functional genomics framework for effective identification of novel regulatory variants in genome–phenome studies

from Genome Medicine

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Antagonistic pleiotropy and mutation accumulation influence human senescence and disease

from Nature Ecology & Evolution

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Are genetic polymorphisms in the renin–angiotensin–aldosterone system associated with essential hypertension? Evidence from genome-wide association studies

from Journal of Human Hypertension

Are minor alleles more likely to be risk alleles?

from BMC Medical Genomics

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Are Polymorphisms in Genes Relevant to Drug Disposition Predictors of Susceptibility to Drug-Induced Liver Injury?

from Pharmaceutical Research

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Associating cellular epigenetic models with human phenotypes

from Nature Reviews Genetics

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Attempts to replicate genetic associations with schizophrenia in a cohort from north India

from npj Schizophrenia

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Beyond genomics: understanding exposotypes through metabolomics

from Human Genomics

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Big data mining powers fungal research: recent advances in fission yeast systems biology approaches

from Current Genetics

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Craniofacial shape transition across the house mouse hybrid zone: implications for the genetic architecture and evolution of between-species differences

from Development Genes and Evolution

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Detecting positive selection in the genome

from BMC Biology

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Dosage compensation and its roles in evolution of sex chromosomes and phenotypic dimorphism: lessons from Drosophila, C.elegans and mammals

from The Nucleus

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Effect of genetic architecture on the prediction accuracy of quantitative traits in samples of unrelated individuals

from Heredity

Elevation of soybean seed oil content through selection for seed coat shininess

from Nature Plants

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Empirical estimation of genome-wide significance thresholds based on the 1000 Genomes Project data set

from Journal of Human Genetics

Ensemble genomic analysis in human lung tissue identifies novel genes for chronic obstructive pulmonary disease

from Human Genomics

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Further evidence for the genetic association between CACNA1I and schizophrenia

from Hereditas

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Genetic and epigenetic influences on the loss of tolerance in autoimmunity

from Cellular and Molecular Immunology

Genetic dissection of acetic acid tolerance in Saccharomyces cerevisiae

from World Journal of Microbiology and Biotechnology

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Genome wide association study (GWAS) for grain yield in rice cultivated under water deficit

from Genetica

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Genome-wide analysis of SU(VAR)3-9 distribution in chromosomes of Drosophila melanogaster

from Chromosoma

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Genome-wide association studies dissect the genetic networks underlying agronomical traits in soybean

from Genome Biology

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Genome-wide association study of classical Hodgkin lymphoma identifies key regulators of disease susceptibility

from Nature Communications

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Genome-wide association study reveals genetic architecture of coleoptile length in wheat

from Theoretical and Applied Genetics

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Genome-wide association study using the ethnicity-specific Japonica array: identification of new susceptibility loci for cold medicine-related Stevens–Johnson syndrome with severe ocular complications

from Journal of Human Genetics

Genome-wide characteristics of de novo mutations in autism

from npj Genomic Medicine

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Genome-wide characterization of genetic variants and putative regions under selection in meat and egg-type chicken lines

from BMC Genomics

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Genome-wide compound heterozygote analysis highlights alleles associated with adult height in Europeans

from Human Genetics

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Genomic tools for behavioural ecologists to understand repeatable individual differences in behaviour

from Nature Ecology & Evolution

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Hepatocyte Nuclear Factor 4 Alpha and Farnesoid X Receptor Co-regulates Gene Transcription in Mouse Livers on a Genome-Wide Scale

from Pharmaceutical Research

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Heterosis as a consequence of regulatory incompatibility

from BMC Biology

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Improving power and accuracy of genome-wide association studies via a multi-locus mixed linear model methodology

from Scientific Reports

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Increased brain expression of GPNMB is associated with genome wide significant risk for Parkinson’s disease on chromosome 7p15.3

from Neurogenetics

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Intergenic disease-associated regions are abundant in novel transcripts

from Genome Biology

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Item-level analyses reveal genetic heterogeneity in neuroticism

from Nature Communications

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Locus and gene-based GWAS meta-analysis identifies new diabetic nephropathy genes

from Immunogenetics

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Multiple across-strain and within-strain QTLs suggest highly complex genetic architecture for hypoxia tolerance in channel catfish

from Molecular Genetics and Genomics

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Network-based machine learning and graph theory algorithms for precision oncology

from npj Precision Oncology

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New technologies accelerate the exploration of non-coding RNAs in horticultural plants

from Horticulture Research

Non-coding RNAs demystify constitutive heterochromatin as essential modulator of epigenotype

from The Nucleus

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Novel loci and pathways significantly associated with longevity

from Scientific Reports

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Regulation of disease-associated gene expression in the 3D genome

from Nature Reviews Molecular Cell Biology

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Requirement or exclusion of inverted repeat sequences with cruciform-forming potential in Escherichia coli revealed by genome-wide analyses

from Current Genetics

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Schizophrenia genetics comes to translation

from npj Schizophrenia

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Siglec genes confer resistance to systemic lupus erythematosus in humans and mice

from Cellular and Molecular Immunology

Spaceflight modulates gene expression in the whole blood of astronauts

from npj Microgravity

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Strategic Applications of Gene Expression: From Drug Discovery/Development to Bedside

from AAPS Journal

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The adaptation of Escherichia coli cells grown in simulated microgravity for an extended period is both phenotypic and genomic

from npj Microgravity

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The importance of cohort studies in the post-GWAS era

from Nature Genetics

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The master regulator PhoP coordinates phosphate and nitrogen metabolism, respiration, cell differentiation and antibiotic biosynthesis: comparison in Streptomyces coelicolor and Streptomyces avermitilis

from The Journal of Antibiotics

The new genetics of intelligence

from Nature Reviews Genetics

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The NSIGHT1-randomized controlled trial: rapid whole-genome sequencing for accelerated etiologic diagnosis in critically ill infants

from npj Genomic Medicine

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Wheat miRNA ancestors: evident by transcriptome analysis of A, B, and D genome donors

from Functional & Integrative Genomics

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Recommended books

9783319631707

Genomic Selection for Crop Improvement

New Molecular Breeding Strategies for Crop Improvement

Editors: Rajeev K. Varshney, Manish Roorkiwal, Mark E.Sorrells

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9783319493299

Comparative and Evolutionary Genomics of Angiosperm Trees

Editors: Andrew Groover, Quentin Cronk

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