Precision medicine

Browse key articles nominated by our Editors

30 years of Oncogene

from Oncogene

5-Hydroxymethylcytosine signatures in cell-free DNA provide information about tumor types and stages

from Cell Research

ARID1A-mutated ovarian cancers depend on HDAC6 activityJournal article Number 3

from Nature Cell Biology

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Blocking the recruitment of naive CD4+ T cells reverses immunosuppression in breast cancer

from Cell Research

 

Cascade Impactor (CI) Mensuration—An Assessment of the Accuracy and Precision of Commercially Available Optical Measurement Systems

from AAPS PharmSciTech

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Chromosomal breaks at FRA18C: association with reduced DOK6 expression, altered oncogenic signaling and increased gastric cancer survival

from npj Precision Oncology

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Evaluation of reported pathogenic variants and their frequencies in a Japanese population based on a whole-genome reference panel of 2049 individuals

from Journal of Human Genetics

Fighting against evolution of antibiotic resistance by utilizing evolvable antimicrobial drugs

from Current Genetics

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From public health genomics to precision public health: a 20-year journey

from Genetics in Medicine

From somatic variants towards precision oncology: Evidence-driven reporting of treatment options in molecular tumor boards

from Genome Medicine

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Genotype-related variations in proinflammatory and regulatory cytokine levels in treated and treatment-naive HCV-infected patients

from Medical Microbiology and Immunology

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Germline hypomorphic CARD11 mutations in severe atopic disease

from Nature Genetics

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Human genomics projects and precision medicine

from Gene Therapy

Identification and targeting of an FGFR fusion in a pediatric thalamic “central oligodendroglioma”

from npj Precision Oncology

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Impact of ACE2 gene polymorphism on antihypertensive efficacy of ACE inhibitors

from Journal of Human Hypertension

Impacts of incorporating personal genome sequencing into graduate genomics education: a longitudinal study over three course years

from BMC Medical Genomics

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In situ regeneration of retinal pigment epithelium by gene transfer of E2F2: a potential strategy for treatment of macular degenerations

from Gene Therapy

Integrative omics for health and disease

from Nature Reviews Genetics

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Intestinal Stem Cells to Advance Drug Development, Precision, and Regenerative Medicine: A Paradigm Shift in Translational Research

from The AAPS Journal

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Isocitrate dehydrogenase mutations in myeloid malignancies

from Leukemia

Metabolomics enables precision medicine: “A White Paper, Community Perspective”

from Metabolomics

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Mining the transcriptome for rare disease therapies: a comparison of the efficiencies of two data mining approaches and a targeted cell-based drug screen

from npj Genomic Medicine

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Muscle-specific CRISPR/Cas9 dystrophin gene editing ameliorates pathophysiology in a mouse model for Duchenne muscular dystrophy

from Nature Communications

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Nanotechnology as a Delivery Tool for Precision Cancer Therapies

from The AAPS Journal

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Nrl knockdown by AAV-delivered CRISPR/Cas9 prevents retinal degeneration in mice

from Nature Communications

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Pharmacometabolomics and Precision Medicine Special Issue Editorial

from Metabolomics

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Phenotypic profiling of CFTR modulators in patient-derived respiratory epithelia

from npj Genomic Medicine

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Precision antimicrobial therapeutics: the path of least resistance?

from npj Biofilms and Microbiomes

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Precision Medicine: Genetic Repair of Retinitis Pigmentosa in Patient-Derived Stem Cells

from Scientific Reports

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Precision Ocular Drug Delivery Via Aerosol Ring Vortices

from Pharmaceutical Research

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Prospects for strain-specific immunotherapy in Alzheimer’s disease and tauopathies

from npj Vaccines

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Proteasome inhibition suppresses Th17 cell generation and ameliorates autoimmune development in experimental Sjögren’s syndrome

from Cellular & Molecular Immunology

Re-educating immunity in respiratory allergies: the potential for hematopoietic stem cell-mediated gene therapy

from Journal of Molecular Medicine

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Representing a “revolution”: how the popular press has portrayed personalized medicine

from Genetics in Medicine

Role of serum level and genetic variation of IL-28B in interferon responsiveness and advanced liver disease in chronic hepatitis C patients

from Medical Microbiology and Immunology

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Synthetic lethal targeting of RNF20 through PARP1 silencing and inhibition

from Cellular Oncology

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T-bet promotes potent antitumor activity of CD4+ CAR T cells

from Cancer Gene Therapy

The impact of next-generation sequencing technologies on HLA research

from Journal of Human Genetics

The promise of discovering population-specific disease-associated genes in South Asia

from Nature Genetics

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Towards precision medicine

from Nature Reviews Genetics

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Using gene expression data to direct breast cancer therapy: evidence from a preclinical trial

from Journal of Molecular Medicine

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Using information of relatives in genomic prediction to apply effective stratified medicine

from Scientific Reports

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ZSCAN10 expression corrects the genomic instability of iPSCs from aged donors

from Nature Cell Biology

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