Coronavirus Trials

ISRCTN

ISRCTN is a clinical trial registry recognized by the WHO and ICMJE that accepts planned, ongoing or completed studies of any design. Below you will find a selection of recent trials related to COVID-19. Further trials can be found on the ISRCTN site.

Adaptive COVID-19 treatment trial in the EU & UKA platform to investigate the safety and effectiveness of several new medicines for the treatment of COVID-19 in hospitalised patientsAn international platform trial for severely ill patients with community-acquired pneumonia or COVID-19A phase II/III study to determine the efficacy, safety and immunogenicity of the candidate coronavirus disease (COVID-19) vaccine ChAdOx1 nCoV-19
A phase III randomized controlled trial to determine safety, efficacy, and immunogenicity of the non-replicating ChAdOx1 nCoV-19 vaccineA single-blind, randomised, phase II study to determine safety and immunogenicity of the Coronavirus Disease (COVID-19) vaccine ChAdOx1 in UK healthy children and adolescents (aged 6 - 17 years)A single-blind, randomised, phase II UK multi-centre study to determine reactogenicity and immunogenicity of heterologous prime/boost COVID-19 vaccine schedulesA single-blind, randomized, phase II UK multi-centre study to determine the reactogenicity and immunogenicity of heterologous prime/boost COVID-19 vaccine schedules – stage 2
A single-blind, phase IV UK multi-centre randomised controlled trial to determine reactogenicity and immunogenicity of COVID-19 vaccines administered concomitantly with seasonal influenza vaccinesA phase II/III study to determine the efficacy, safety and immunogenicity of the candidate coronavirus disease (COVID-19) vaccine ChAdOx1 nCoV-19Using blood plasma to develop passive immunity to coronavirus in EcuadorA global registry of women affected by COVID-19 in pregnancy and their babies, to guide treatment and prevention (PAN-COVID)
COVID-19 social study: the effects of quarantine on mental health

Public health emergency SOLIDARITY trial of treatments for COVID-19 infection in hospitalized patients

A trial evaluating treatments for suspected coronavirus infection in people aged 50 years and above with pre-existing conditions and those aged 65 years and aboveDoes point-of-care testing for coronavirus in hospital improve patient care compared to laboratory testing?
Aspergillosis in patients with severe influenza or coronavirus

A phase I/II study to determine efficacy, safety and immunogenicity of the candidate coronavirus disease (COVID-19) vaccine ChAdOx1 nCoV-19 in UK healthy adult volunteer

RECOVERY Respiratory Support: Respiratory Strategies in patients with coronavirus COVID-19 – CPAP, high-flow nasal oxygen, and standard care

A randomised trial of treatments to prevent death in patients hospitalised with COVID-19 (coronavirus)

UKOSS: Pandemic COVID-19 in pregnancyThe impact of the COVID-19 pandemic on the provision, practice, and outcomes of vascular surgery (COVER study)Testing an early online intervention for the treatment of disturbed sleep during the COVID-19 pandemicCohort study for predicting severe disease courses in patients presenting for coronavirus testing to the University of Zurich COVID-19 Testing Center
Comparison of lung water in COVID-19 patients and other patients with acute respiratory failureDistress and resilience of healthcare professionals during the COVID-19 (coronavirus) pandemicDoes taking hydroxychloroquine before and during exposure to patients protect frontline healthcare workers from coronavirus?Can the Ava fertility tracker device detect early signs of COVID-19?
Occupational health and safety among health care personnel in a COVID-19 pandemic