Nobel Prize at Springer Nature

2023 Nobel Prize in Physiology or Medicine

Nobel Prize 2018

On October 2, the Nobel Prize in Physiology or Medicine 2023 was awarded to Katalin Karikó and Drew Weissman "for their discoveries concerning nucleoside base modifications that enabled the development of effective mRNA vaccines against COVID-19."*

This year’s Nobel Laureates didn’t achieve their breakthroughs overnight. Below you can read, share, and download a selection of their research that’s published across Springer Nature’s journals and books. Find the story of this year’s Laureates in Physiology or Medicine.

*The Nobel Prize in Physiology or Medicine 2023. NobelPrize.org. Nobel Prize Outreach AB 2023. Mon. 2 Oct 2023.

Publications by Katalin Karikó

Book chapters

Transfection of Human Keratinocytes with Nucleoside-Modified mRNA Encoding CPD-Photolyase to Repair DNA Damage. In: Synthetic mRNA

Measuring Hematocrit in Mice Injected with In Vitro-Transcribed Erythropoietin mRNA. In: Synthetic mRNA

In Vitro Transcription of Long RNA Containing Modified Nucleosides. In: Synthetic Messenger RNA and Cell Metabolism Modulation

HPLC Purification of In Vitro Transcribed Long RNA. In: Synthetic Messenger RNA and Cell Metabolism Modulation

Neutrophil Depletion Diminishes Monocyte Infiltration and Improves Functional Outcome After Experimental Intracerebral Hemorrhage. In: Intracerebral Hemorrhage Research

A PCR-Based Approach to Hammerhead Ribozyme Synthesis. In: Therapeutic Applications of Ribozymes

View the Special Issue: Novel Contributions to the RNA Story: Karikó’s Legacy here.

Publications by Drew Weissman

Articles

Nucleofection induces transient eIF2α phosphorylation by GCN2 and PERK. Published in: Gene Therapy

SIV antigen immunization induces transient antigen-specific T cell responses and selectively activates viral replication in draining lymph nodes in retroviral suppressed rhesus macaques. Published in: Retrovirology

Inherited Resistance to HIV-1 Conferred by an Inactivating Mutation in CC Chemokine Receptor 5: Studies in Populations with Contrasting Clinical Phenotypes, Defined Racial Background, and Quantified Risk. Published in: Molecular Medicine

A mosquito AgTRIO mRNA vaccine contributes to immunity against malaria. Published in: npj Vaccines

Hepatitis C virus E1 and modified E2 delivered from an mRNA vaccine induces protective immunity. Published in: npj Vaccines

Lipid nanoparticles (LNP) induce activation and maturation of antigen presenting cells in young and aged individuals. Published in: Communications Biology

mRNA-LNP expressing PfCSP and Pfs25 vaccine candidates targeting infection and transmission of Plasmodium falciparum. Published in: npj Vaccines

mRNA vaccines for infectious diseases: principles, delivery and clinical translation. Published in: Nature Reviews Drug Discovery

Ionization and structural properties of mRNA lipid nanoparticles influence expression in intramuscular and intravascular administration. Published in: Communications Biology

more

Nucleoside-modified VEGFC mRNA induces organ-specific lymphatic growth and reverses experimental lymphedema. Published in: Nature Communications

Nucleoside-modified mRNA immunization elicits influenza virus hemagglutinin stalk-specific antibodies. Published in: Nature Communications

Administration of nucleoside-modified mRNA encoding broadly neutralizing antibody protects humanized mice from HIV-1 challenge. Published in: Nature Communications

Zika virus protection by a single low-dose nucleoside-modified mRNA vaccination. Published in: Nature

L_brandstrip_bmc
L_brandstrip_natureresearch
L_brandstrip_springer