Nobel Prize at Springer Nature

2025 Nobel Prize in Physiology or Medicine

Nobel Prize 2018

The 2025 Nobel Prize in Physiology or Medicine has been awarded jointly to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance”.*

This year’s Nobel Laureates didn’t achieve their breakthroughs overnight. Below you can read, share, and download a selection of their research that’s published across Springer Nature’s journals and books. Read the story of this year’s Laureates in Physiology or Medicine.

*The Nobel Prize in Physiology or Medicine 2025 - NobelPrize.org

Publications by Shimon Sakaguchi

Articles

Stimulation of CD25+CD4+ regulatory T cells through GITR breaks immunological self-tolerance

Published in: Nature Immunology

Regulatory T cells in transplantation tolerance

Published in: Nature Reviews Immunology

Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self

Published in: Nature Immunology

Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1 

Published in: Nature

Foxp3 and Aire in thymus-generated Treg cells: a link in self-tolerance 

Published in: Nature Immunology

Regulatory T cells exert checks and balances on self tolerance and autoimmunity

Published in: Nature Immunology

FOXP3+ regulatory T cells in the human immune system Published in: Nature Immunology

Re-establishing immunological self-tolerance in autoimmune disease

Published in: Nature Medicine

Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota

Published in: Nature

more

Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota Published in: Nature

The plasticity and stability of regulatory T cells

Published in: Nature Reviews Immunology

Regulatory T cells: recommendations to simplify the nomenclature

Published in: Nature Immunology

TREG-cell therapies for autoimmune rheumatic disease 

Published in: Nature Reviews Rheumatology

Guidance of regulatory T cell development by Satb1-dependent super-enhancer establishment

Published in: Nature Immunology

Two FOXP3+CD4+ T cell subpopulations distinctly control the prognosis of colorectal cancers

Published in: Nature Medicine

Dispensable roles of Gsdmd and Ripk3 in sustaining IL-1β production and chronic inflammation in Th17-mediated autoimmune arthritis

Published in: Scientific Reports

Tumour grade significantly correlates with total dysfunction of tumour tissue-infiltrating lymphocytes in renal cell carcinoma

Published in: Scientific Reports

Regulatory T cells in autoimmune kidney diseases and transplantation

Published in: Nature Reviews Nephrology

Genome-wide CRISPR screen in human T cells reveals regulators of FOXP3

Published in: Nature

Treg cells augment self-tolerance during infection

Published in: Nature Immunology

 

Book chapters

Protocol: Regulatory T Cells: History and Perspective

In: Methods in Molecular Biology, Volume 707

Regulatory T Cells for Control of Autoimmunity

In: Basic Immunology and Its Clinical Application

Control of Regulatory T Cells by Co-signal Molecules

In: Co-signal Molecules in T Cell Activation

Devising Novel Methods to Control Chronic Inflammation Via Regulatory T Cells,

In: Chronic Inflammation 

Thymic Mechanisms for Inducing Tolerance to Mls

In: Mechanisms of Lymphocyte Activation and Immune Regulation III

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